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Beta Glucan - Medline Studies
Last Updated: 01/16/2012


 




These are just a few of the many Medline studies on Beta Glucan. The studies do not reflect the results of any one product, or product line(s) shown to contain Beta Glucan.

Also, the delivery methods of Beta Glucan to the test subjects may have been of different types, two of which are oral and intravenous delivery. You may research Beta Glucan, for yourself, on MEDLINE. MEDLINE is one of the largest medical research/studies archive in the world. Their Internet Address may be found at: http://www.ncbi.nlm.nih.gov/

ABDOMINAL OR THORACIC SURGERY - HARVARD MEDICAL SCHOOL (USA)
"There were no adverse drug experiences....is safe and appears to be effective in the further reduction of the morbidity and cost of major surgery."

BACTERIAL INFECTIONS - BAYLOR COLLEGE OF MEDICINE; Wyde, P.,
"Beta-1,3-glucan activity in mice: intraperitoneal and oral applications." " Beta glucan, through the stimulation of host defense systems, creates a more supportive environment within the body to assist the primary killing action of the conventional agent."

CANCER - CHEM PHARM BULL (Japan);
"Antitumor and immunomodulating activities of a beta-glucan...."

CANCER, LUNG AND BREAST - NATIONAL CANCER INSTITUTE (USA);
"The initial 9 patients studied had malignant melanoma, adenosquamous carcinoma of the lung, or carcinoma of the breast. Control and experimental lesions were injected: subsequently biopsies were performed at varying intervals for histologic evaluation. Always when glucan or glucan and RF fraction were administered intralesionally, the size of the lesion was strikingly reduced in as short a period as 5 days. This reduction was associated with necrosis of the tumor and a monocytic infiltrate. In small lesions, resolution was complete, whereas in large lesions, resolution was partial.

CANCER - MAYO CLINIC (USA);
"..... beta-glucan interacts with vitronectin and stimulates tumor necrosis factor alpha release from macrophage's."

CANCER - UNIVERSITY OF TROMSO (Norway);
"Macrophages stimulated by an insoluble beta 1-3-D-glucan from yeast cell walls were able to destroy tumour cells as measured by the release of radioactive label from prelabelled 14C-thymidine cells. Target cells were B-16 melanoma, P-815 mastocytoma, and the L-929 cell line. A significant target cell killing by macrophages stimulated by glucan was observed after 72-96 h."

CANDIDA ALBICANS - DEPARTMENT OF SURGERY, TULANE UNIVERSITY;
"Protection against C. albicans was observed in the glucan-treated groups. ...These observations suggest that Biologic Response Modifiers such as glucan may be effectively employed in patients who are at risk for post-operative infections."

CHOLESTEROL (LDL) - OTTAWA CIVIC HOSPITAL (Canada);
"CONCLUSIONS: The main component of the soluble fiber of oats, beta-glucan, significantly reduced the total and LDL cholesterol levels of hypercholesterolemic adults without changing HDL cholesterol."

CHOLESTEROL - DEPARTMENT OF AGRICULTURE (USA);
"Beneficial reduction of cholesterol was obtained with modest amounts....."

DIABETES - OTTAWA CIVIC HOSPITAL (Canada);
"A diet rich in beta-glucan may therefore be of benefit in the regulation of plasma glucose levels in subjects with Type 2 diabetes."

DIABETES - NESTLAE RESEARCH CENTER (Switzerland);
"Diabetic individuals can benefit from diets that are high in beta-glucan, .."

E. COLI - TULANE UNIVERSITY (USA, La);
"Glucan therapy also increased bone marrow proliferation. We conclude that (1) glucan enhances peritoneal neutrophil levels, (2) Peripheral blood neutrophils are increased following glucan and E. coli, (3) ip glucan increase bone marrow proliferation, .... Thus, the beneficial effect of glucan is mediated not only by activated macrophages, but also by the neutrophilic leukocyte."

E. COLI, STAPHYLOCOCCUS - DEPARTMENT OF PATHOLOGY, BRIGHAM AND WOMEN'S HOSPITAL (USA, Mass)
"Mice challenged with Escherichia coli or Staphylococcus aureus were protected against lethal peritonitis by the intravenous administration of 10 micrograms of poly-beta 1-6-glucotriosyl-beta 1-3-glucopyranose (PGG) glucan per animal 4 to 6 h prior to bacterial challenge."

FUNGAL INFECTION - TULANE UNIVERSITY;
"The broad spectrum of immunopharmacological activities of glucan includes not only the modification of certain bacterial, fungal, viral and parasitic infections, but also inhibition of tumor growth."

HEPATITIS, VIRAL - SCIENCE (1980);
"Thus glucan is capable of increasing survival, inhibiting hepatic necrosis, and maintaining an activated state of phagocytic activity in mice challenged with [mouse hepatitis virus strain] MHV-A59."

HERPES SIMPLEX 1 - PLANTA MED., 62:4, 301-7. (1996);
"The antiviral effect of scleroglucan seems to be related to its binding with membrane glycoproteins of HSV-1 particles which impedes the complex interactions of the virus with the cell plasma membrane."

HIGH RISK SURGICAL PATIENTS - HARVARD MEDICAL SCHOOL (USA);
"Patients who received PGG-glucan had significantly fewer infectious complications (3.4 infections per infected patient vs. 1.4 infections per infected patient, p = 0.05), decreased intravenous antibiotic requirement (10.3 days vs. 0.4 days, p = 0.04) and shorter intensive care unit length of stay (3.3 days vs. 0.1 days, p = 0.03). CONCLUSIONS: PGG-glucan is safe and appears to be effective in the further reduction of the morbidity and cost of major surgery.

INFECTION PREVENTION - GYNECOLOGY & OBSTETRICS, 177:383-388. (1993);
"The incidence of hospital pneumonia of 55% and sepsis of 35% confirms results of previous studies of patients with multitrauma. Glucan decreased pneumonia and sepsis to a significantly lower level of 9.5%....The mortality rate related to infection decreased from 30.0 to 4.8%. The lower number of instances of pneumonia and sepsis....decreased the period of time in the intensive care and the hospital, with a global reduction of 40% on hospital cost."

INTERLEUKIN - INT J IMMUNOPHARMACOL, 1987, 9:3, 261-7;
"The study demonstrates that; (1) glucan will enhance IL-1 and IL-2 production and (2) elevations in lymphokine production can be maintained up to 12 days post-glucan"

PARASITES - TULANE UNIVERSITY (USA);
"Trypanosoma cruzi, the causative agent of Chagas' disease, infects humans and animals..... Glucan significantly (P less than 0.05) increased survival rate as denoted by 60%...."

PNEUMONIA - HOSPITAL ARTHUR RIBEIRO DE SABOYA (Brazil);
"The mortality rate related to infection was 30.0 percent in patients in the control group and 4.8 percent in the group treated with glucan...."

RADIATION - RADIOPROTECTIVE EFFECT;
"These results suggest that early after irradiation glucan may mediate its radioprotection by enhancing resistance to microbial invasion via mechanisms not necessarily predicated on hemopoietic recovery. In addition, preliminary evidence suggests that glucan can also function as an effective free-radical scavenger."

RADIATION SURVIVABILITY- ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE (USA);
"Immunomodulators, either microbial agents (e.g. glucan, TDM) or recombinant cytokines (e.g. Interleukin-1, colony-stimulating factor), can enhance hematopoietic and functional cell recovery after irradiation."

RADIATION SURVIVABILITY; Abstract:
"Glucan, a beta-1, 3 polyglucose, was administered to mice either 1h before or 1h after a 650 rad exposure to cobalt-60 radiation. Compared to radiation controls, glucan-treated mice consistently exhibited a more rapid recovery of pluripotent stem cells and committed granulocyte, macrophage and erythroid progenitor cells. This may partially explain the mechanism by which glucan also enhances survival in otherwise lethally irradiated mice."

STAPHYLOCOCCAL WOUND INFECTION - VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (USA);
"We conclude that PGG Glucan reduces the risk of staphylococcal abscess formation."

STRESS, PHYSICAL, OR EMOTIONAL - TOWNSEND LETTER FOR DOCTORS, (1996);
"The following list includes benefits from the use of Beta 1,3-glucan supplementation: Professional and amateur athletes as well as people who work outdoors intensively. People under physical or emotional stress"

TRAUMA PATIENTS - TULANE UNIVERSITY (USA);
"total mortality rate was significantly less in the glucan group (0% versus 29%) (p less then 0.05), the mortality rate from sepsis was not statistically different (0% versus 17.6%). Glucan therapy significantly decreased septic morbidity (9.5% versus 49%; p less than 0.05). Serum IL-1 had a greater increase in glucan patients on day 3 after trauma (143.4 +/- 19.3% versus 78.6 +/- 11.7%; p less than 0.05),..."

WOUND HEALING - EAST TENNESSEE STATE UNIVERSITY (USA);
"These data indicate that macrophage modulation with glucan phosphate will increase tensile strength in experimental colon and skin wounds."




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