These are just a few of the many Medline studies on Beta Glucan.
The studies do not reflect the results of any one product, or product
line(s) shown to contain Beta Glucan.
Also, the delivery methods of Beta Glucan to the test subjects may
have been of different types, two of which are oral and intravenous
delivery. You may research Beta Glucan, for yourself, on MEDLINE.
MEDLINE is one of the largest medical research/studies archive in the
world. Their Internet Address may be found at: http://www.ncbi.nlm.nih.gov/
ABDOMINAL OR THORACIC SURGERY - HARVARD MEDICAL
"There were no adverse drug experiences....is
safe and appears to be effective in the further reduction of the
morbidity and cost of major surgery."
BACTERIAL INFECTIONS - BAYLOR COLLEGE OF
MEDICINE; Wyde, P.,
"Beta-1,3-glucan activity in mice:
intraperitoneal and oral applications." " Beta glucan,
through the stimulation of host defense systems, creates a more
supportive environment within the body to assist the primary killing
action of the conventional agent."
CANCER - CHEM PHARM BULL (Japan);
and immunomodulating activities of a beta-glucan...."
CANCER, LUNG AND BREAST - NATIONAL CANCER
"The initial 9 patients studied had
malignant melanoma, adenosquamous carcinoma of the lung, or carcinoma
of the breast. Control and experimental lesions were injected:
subsequently biopsies were performed at varying intervals for
histologic evaluation. Always when glucan or glucan and RF fraction
were administered intralesionally, the size of the lesion was
strikingly reduced in as short a period as 5 days. This reduction was
associated with necrosis of the tumor and a monocytic infiltrate. In
small lesions, resolution was complete, whereas in large lesions,
resolution was partial.
CANCER - MAYO CLINIC (USA);
beta-glucan interacts with vitronectin and stimulates tumor necrosis
factor alpha release from macrophage's."
CANCER - UNIVERSITY OF TROMSO (Norway);
"Macrophages stimulated by an insoluble beta 1-3-D-glucan
from yeast cell walls were able to destroy tumour cells as measured
by the release of radioactive label from prelabelled 14C-thymidine
cells. Target cells were B-16 melanoma, P-815 mastocytoma, and the
L-929 cell line. A significant target cell killing by macrophages
stimulated by glucan was observed after 72-96 h."
CANDIDA ALBICANS - DEPARTMENT OF SURGERY, TULANE
"Protection against C. albicans was observed in
the glucan-treated groups. ...These observations suggest that
Biologic Response Modifiers such as glucan may be effectively
employed in patients who are at risk for post-operative infections."
CHOLESTEROL (LDL) - OTTAWA CIVIC HOSPITAL
"CONCLUSIONS: The main component of the soluble
fiber of oats, beta-glucan, significantly reduced the total and LDL
cholesterol levels of hypercholesterolemic adults without changing
CHOLESTEROL - DEPARTMENT OF AGRICULTURE (USA);
"Beneficial reduction of cholesterol was obtained with
DIABETES - OTTAWA CIVIC HOSPITAL (Canada);
diet rich in beta-glucan may therefore be of benefit in the
regulation of plasma glucose levels in subjects with Type 2
DIABETES - NESTLAE RESEARCH CENTER (Switzerland);
"Diabetic individuals can benefit from diets that are high
in beta-glucan, .."
E. COLI - TULANE UNIVERSITY (USA, La);
therapy also increased bone marrow proliferation. We conclude that
(1) glucan enhances peritoneal neutrophil levels, (2) Peripheral
blood neutrophils are increased following glucan and E. coli, (3) ip
glucan increase bone marrow proliferation, .... Thus, the beneficial
effect of glucan is mediated not only by activated macrophages, but
also by the neutrophilic leukocyte."
E. COLI, STAPHYLOCOCCUS - DEPARTMENT OF
PATHOLOGY, BRIGHAM AND WOMEN'S HOSPITAL (USA, Mass)
challenged with Escherichia coli or Staphylococcus aureus were
protected against lethal peritonitis by the intravenous
administration of 10 micrograms of poly-beta 1-6-glucotriosyl-beta
1-3-glucopyranose (PGG) glucan per animal 4 to 6 h prior to bacterial
FUNGAL INFECTION - TULANE UNIVERSITY;
broad spectrum of immunopharmacological activities of glucan includes
not only the modification of certain bacterial, fungal, viral and
parasitic infections, but also inhibition of tumor growth."
HEPATITIS, VIRAL - SCIENCE (1980);
glucan is capable of increasing survival, inhibiting hepatic
necrosis, and maintaining an activated state of phagocytic activity
in mice challenged with [mouse hepatitis virus strain] MHV-A59."
HERPES SIMPLEX 1 - PLANTA MED., 62:4, 301-7.
"The antiviral effect of scleroglucan seems to be
related to its binding with membrane glycoproteins of HSV-1 particles
which impedes the complex interactions of the virus with the cell
HIGH RISK SURGICAL PATIENTS - HARVARD MEDICAL
"Patients who received PGG-glucan had
significantly fewer infectious complications (3.4 infections per
infected patient vs. 1.4 infections per infected patient, p = 0.05),
decreased intravenous antibiotic requirement (10.3 days vs. 0.4 days,
p = 0.04) and shorter intensive care unit length of stay (3.3 days
vs. 0.1 days, p = 0.03). CONCLUSIONS: PGG-glucan is safe and appears
to be effective in the further reduction of the morbidity and cost of
INFECTION PREVENTION - GYNECOLOGY &
OBSTETRICS, 177:383-388. (1993);
"The incidence of hospital
pneumonia of 55% and sepsis of 35% confirms results of previous
studies of patients with multitrauma. Glucan decreased pneumonia and
sepsis to a significantly lower level of 9.5%....The mortality rate
related to infection decreased from 30.0 to 4.8%. The lower number of
instances of pneumonia and sepsis....decreased the period of time in
the intensive care and the hospital, with a global reduction of 40%
on hospital cost."
INTERLEUKIN - INT J IMMUNOPHARMACOL, 1987, 9:3,
"The study demonstrates that; (1) glucan will enhance
IL-1 and IL-2 production and (2) elevations in lymphokine production
can be maintained up to 12 days post-glucan"
PARASITES - TULANE UNIVERSITY (USA);
"Trypanosoma cruzi, the causative agent of Chagas' disease,
infects humans and animals..... Glucan significantly (P less than
0.05) increased survival rate as denoted by 60%...."
PNEUMONIA - HOSPITAL ARTHUR RIBEIRO DE SABOYA
"The mortality rate related to infection was 30.0
percent in patients in the control group and 4.8 percent in the group
treated with glucan...."
RADIATION - RADIOPROTECTIVE EFFECT;
results suggest that early after irradiation glucan may mediate its
radioprotection by enhancing resistance to microbial invasion via
mechanisms not necessarily predicated on hemopoietic recovery. In
addition, preliminary evidence suggests that glucan can also function
as an effective free-radical scavenger."
RADIATION SURVIVABILITY- ARMED FORCES
RADIOBIOLOGY RESEARCH INSTITUTE (USA);
either microbial agents (e.g. glucan, TDM) or recombinant cytokines
(e.g. Interleukin-1, colony-stimulating factor), can enhance
hematopoietic and functional cell recovery after irradiation."
RADIATION SURVIVABILITY; Abstract:
a beta-1, 3 polyglucose, was administered to mice either 1h before or
1h after a 650 rad exposure to cobalt-60 radiation. Compared to
radiation controls, glucan-treated mice consistently exhibited a more
rapid recovery of pluripotent stem cells and committed granulocyte,
macrophage and erythroid progenitor cells. This may partially explain
the mechanism by which glucan also enhances survival in otherwise
lethally irradiated mice."
STAPHYLOCOCCAL WOUND INFECTION - VANDERBILT
UNIVERSITY SCHOOL OF MEDICINE (USA);
"We conclude that PGG
Glucan reduces the risk of staphylococcal abscess formation."
STRESS, PHYSICAL, OR EMOTIONAL - TOWNSEND LETTER
FOR DOCTORS, (1996);
"The following list includes benefits
from the use of Beta 1,3-glucan supplementation: Professional and
amateur athletes as well as people who work outdoors intensively.
People under physical or emotional stress"
TRAUMA PATIENTS - TULANE UNIVERSITY (USA);
"total mortality rate was significantly less in the glucan
group (0% versus 29%) (p less then 0.05), the mortality rate from
sepsis was not statistically different (0% versus 17.6%). Glucan
therapy significantly decreased septic morbidity (9.5% versus 49%; p
less than 0.05). Serum IL-1 had a greater increase in glucan patients
on day 3 after trauma (143.4 +/- 19.3% versus 78.6 +/- 11.7%; p less
WOUND HEALING - EAST TENNESSEE STATE UNIVERSITY
"These data indicate that macrophage modulation with
glucan phosphate will increase tensile strength in experimental colon
and skin wounds."